Kernig's Sign is indicative of which condition during a physical examination?

Kernig's Sign is specifically associated with meningeal irritation, often seen in conditions such as meningitis. This sign is tested by flexing the patient's hip and knee to 90 degrees and then attempting to extend the knee. If this action causes pain or resistance, it suggests irritation of the meninges, which can occur with inflammation or infection.

The presence of Kernig's Sign supports the diagnosis of meningitis because it indicates that the protective membranes surrounding the brain and spinal cord are inflamed, causing discomfort during passive movements of the lower extremities. This kind of neurological sign is particularly significant during examinations aimed at diagnosing central nervous system infections or insults.

In contrast, other conditions like increased intracranial pressure, peripheral neuropathy, and muscle strain may present with different symptoms or signs that are not specifically linked to meningeal irritation. Therefore, the identification of Kernig's Sign is most directly indicative of meningeal irritation.