What combination of therapies is considered best for secondary prevention after a stroke?

The best combination of therapies for secondary prevention after a stroke often involves the use of anticoagulation for conditions like atrial fibrillation along with antiplatelet therapy. This approach is particularly indicated for patients who have experienced an ischemic stroke due to atrial fibrillation, where the risk of further embolic events is heightened. Anticoagulation helps to prevent the formation of new clots, while antiplatelet agents reduce the aggregation of platelets, thus addressing both thromboembolic and vascular risks.

In the context of secondary prevention, maintaining optimal blood flow and preventing future cerebrovascular events is crucial. The combined effect of these therapies helps manage underlying conditions that contribute to stroke risk, targeting both endothelial health and clot formation mechanisms.

While other therapies such as statins and blood pressure medications play an essential role in managing cardiovascular risk factors, they may not directly address specific scenarios like atrial fibrillation-related strokes as effectively as the combination of anticoagulation and antiplatelet therapy. Similarly, rehabilitation measures, including physical and occupational therapy, although important for recovery, do not directly prevent future strokes. Dietary changes and exercise are beneficial lifestyle modifications that can support overall cardiovascular health but are typically part of a broader secondary prevention strategy rather than a