What is the primary mechanism of action for tPA?

The primary mechanism of action for tPA, or tissue plasminogen activator, is that it activates plasminogen to dissolve blood clots. In the setting of an acute ischemic stroke, tPA works by converting plasminogen, which is found in the blood, into plasmin. Plasmin is an enzyme that breaks down fibrin, the main component of blood clots. By promoting the breakdown of these clots, tPA helps restore blood flow to the affected areas of the brain, improving outcomes for patients who have experienced a stroke.

This targeted action of tPA emphasizes its role as a thrombolytic agent in the management of ischemic strokes, enabling timely intervention to minimize brain damage and long-term disability. Understanding this mechanism is crucial for stroke care providers, as it underpins the rationale for early intervention with tPA following ischemic events.